Application of a newly developed ELISA for BCAR1 protein for prediction of clinical benefit of tamoxifen therapy in patients with advanced breast cancer.

نویسندگان

  • Lambert C J Dorssers
  • Nicolai Grebenchtchikov
  • Arend Brinkman
  • Maxime P Look
  • Jan G M Klijn
  • Anneke Geurts-Moespot
  • Paul N Span
  • John A Foekens
  • C G J Fred Sweep
چکیده

Protein for Prediction of Clinical Benefit of Tamoxifen Therapy in Patients with Advanced Breast Cancer, Lambert C.J. Dorssers, Nicolai Grebenchtchikov, Arend Brinkman, Maxime P. Look, Jan G.M. Klijn, Anneke GeurtsMoespot, Paul N. Span, John A. Foekens, and C.G.J. (Fred) Sweep ( Department of Pathology, Division of Molecular Biology, and 3 Department of Medical Oncology, Erasmus MC Rotterdam, Rotterdam, The Netherlands; 2 Department of Chemical Endocrinology, University Medical Centre Nijmegen, Nijmegen, The Netherlands; * address correspondence to this author at: Department of Chemical Endocrinology, University Medical Centre Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands; fax 31243541484, e-mail [email protected])

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منابع مشابه

Development of an ELISA for measurement of BCAR1 protein in human breast cancer tissue.

BACKGROUND High concentrations of breast cancer anti-estrogen resistance 1 (BCAR1) protein measured by Western blotting in primary breast tumor cytosols are associated with early disease progression and failure of tamoxifen therapy. The aim of the present study was to develop an ELISA to measure BCAR1 quantitatively in extracts of human breast cancer tissue. METHODS A recombinant fragment of ...

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The Effects of Tamoxifen in Combination with Tranilast on CXCL12- CXCR4 Axis and Invasion in Breast Cancer Cell Lines

It has been reported that CXCL12 binding to CXCR4 induces several intracellular signaling pathways, and enhances survival, proliferation, and migration of malignant cells. Herein we examined the effects of anti-estrogen tamoxifen and anti-allergic tranilast drugs as a single or in combination on invasion by two in vitro invasion assays, wound-healing and matrigel invasion on MCF-7 and MDA-MB-23...

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Sonohysterography for evaluation of endometrial abnormalities in breast cancer patients under tamoxifen therapy

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 Background & Aims: Tamoxifen is used in breast cancer as adjuvant hormonal therapy. Some studies have found effect of tamoxifen on bile components and gallstone formation. The purpose of the study was to find out the association between tamoxifen use in patient with breast cancer and gallstone formation. Materials & Methods: 780 patient with breast cancer who had undergone surgery in 3 hospita...

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عنوان ژورنال:
  • Clinical chemistry

دوره 50 8  شماره 

صفحات  -

تاریخ انتشار 2004